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Important consideration: the medication requires strict dosing protocol, including being taken first thing in the morning on an empty stomach with no more than 4 ounces of water, with a 30-minute wait before eating or drinking

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J Clin Anesth 2023

Peripheral sensitization happens at the nerve endings themselves

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Studies conducted with Caco-2 cells in a laboratory setting, utilizing inhibitors of transporter proteins and knockout methods, have pinpointed the main transporter proteins responsible for metformin as the organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), serotonin transporter (SERT), and high-affinity choline transporter (CHT) (Han et al., 2015)