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Considering the previously discussed information, GLP-1 analogues, by interacting with key structures within the reward circuitrysuch as the mesolimbic and corticolimbicstriatal systemsmay influence the distinct phases of the addiction cycle, including intoxication, withdrawal, and anticipation/craving [41]

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PMID: 38265519

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Integrative approaches combining GWAS with transcriptomic, epigenomic, and single-cell approaches are increasingly important for uncovering causal variants and cell-specific regulatory circuits

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