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Building on these results, a phase 1b trial in individuals with T2D further evaluated the safety, pharmacokinetics, and pharmacodynamics of once-weekly retatrutide over 12 weeks [43]

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Recent systematic analyses highlighted both sequence polymorphisms and epigenetic modifications (promoter methylation) as contributors to heterogeneous treatment outcomes, underscoring a multifactorial genetic architecture rather than a single predictive marker [27-29]

It is commonly prescribed off-label, often as a compounded topical cream or as a reduced dose of a testosterone gel (1%) FDA approved for men, Dr