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Reduction of Hyperinsulinaemia and IGF-1 Signalling Elevated circulating insulin and insulin-like growth factor-1 (IGF-1) represent well-established promoters of tumour cell proliferation

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30 Notably, 18% of patients had a prior LVEF 40, and 42% had undocumented LVEF

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In the FIGHT trial on patients hospitalized for HFrEF, Liraglutide did not show benefit on time to death, time to rehospitalization for heart failure, and time-averaged proportional change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels from baseline to 180 days [51]

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