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Per a study published in April in Genome Medicine , people who carried certain mutations in their PAM (peptidyl-gylcine alpha-amidating monooxygenase) genes, which are key for processing hormones, were less likely to respond to GLP-1 drugs

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Incretins are gut-derived hormones, members of the glucagon superfamily

GLP-1 originating from the gut has a very short circulating half-life of only 12 min due to its rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4) and subsequent clearance through the kidneys

When this system is less active, heart rate and blood pressure may decrease, even without significant weight changes

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