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Milder et al

These results have stimulated a number of human physiology studies and preclinical studies that have interrogated potential direct kidney effects of GLP-1 receptor agonists using state-of-the-art phenotyping studies, which are summarized below

Effects on classic cardiovascular risk factors CVOTs on GLP-1RAs Data from the major CVOTs ELIXA, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, LEADER, REWIND, and AMPLITUDE-O [53, 54, 56, 5963] support the overall safety of GLP-1RAs relative to major cardiovascular outcomes

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It is an ecosystem signaling problem

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