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GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R/AMPK pathway

Most studies report the absence [[397], [398], [399]] or very restricted expression of the GLP-1 receptor in a small subset (10%) of -cells [395], and treatment of isolated rat -cells with GLP-1 enhances rather than inhibits the release of glucagon [[604], [605], [606]]

With antiamyloid antibodies Leqembi (lecanemab) and Kisunla (donanemab) now FDAapproved for early Alzheimers, attention is turning to combination strategies that address multiple disease pathways

Remarkably, GIP has been shown to account for about half of the insulinotropic effect upon oral glucose administration in healthy individuals (Elliott et al., 1993