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Recent research shows that bitter substances that activate TAS2R38 can also increase glucagon-like peptide 1 release.[ref] Related article : Bitter Taste Receptors Berberine: One bitter substance that activates TAS2R38 is berberine .[ref] Berberine is readily available as a supplement and also impacts blood glucose levels

& Stephanopoulos, G
Its marketed as a low-effort, natural alternative to GLP-1 medications

A total of 51 studies fulfilled the inclusion criteria

The injectable GLP-1s do have a fairly long half-life, of about four or so weeks

C., Chang, L