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The second is neural, where GLP-1 activates vagal nerve afferents in the gut wall that transmit satiety signals directly to the nucleus tractus solitarius (NTS) in the brainstem
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
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Grover M, Farrugia G, Lurken MS, Bernard CE, Faussonepellegrini MS, Smyrk TC, et al

But the effects of the disease and severity of symptoms vary from person to person

doi: 10.1038/s42255-020-00327-x 16 ZhaoXWangMWenZLuZCuiLFuCet al
Diabetologia 1994 37 1163-1166 Perea A, Vinambres C, Clemente F, Villanueva-Penacarrillo ML & Valverde I
