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Before this trial, no pharmacological therapy had definitively improved hard CV outcomes in HFpEF [19]

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51 Antiapoptotic effects of GLP-1R agonists are associated with activation of PI3K/Akt signaling pathways and downregulation of apoptotic pathways including caspase-3 (CASP3) and poly(adenosine diphosphate ribose) polymerase

Disclosure The author reports no conflicts of interest in this work

and smaller burgers with a lettuce wrap, like those sold at Shake Shack, according to Amy Goodson, a registered dietitian in the Dallas-Fort Worth area who spoke with The Post