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1 Figure 1 shows the numerous physiological effects of GLP-1 agonists, affecting a wide range of systems including the brain, muscle, pancreas, liver and heart

Neutrophils are known to produce IL-1, a key pro-inflammatory cytokine responsible for initiating acute gout attacks characterized by joint redness, swelling, warmth, and pain (45) ( Figure 2 )

Our study underscores the potential of SGLT2i as preferred therapeutic agents for renal protection in patients with type 2 diabetes, although the potential for a sequential combination with a GLP-1RA remains to be ascertained

Most GLP-1 users experience mild nausea, constipation, or reduced appetite intensity during the first 2-4 weeks, which typically resolves as your body adapts
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