retatrutide triple agonist glp-1 gip glucagon phase 2 results hormone receptor for metabolic dysfunction-associated steatotic liver disease: a randomized 2a trial Biggest obesity news 🚨 TRIUMPH-1

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10.1016/j.bone.2021.116065 232 SmirnovK

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Nat Metab (2026)

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This dual mechanism provides: GLP-1 receptor activation: Enhanced glucose-stimulated insulin secretion, slowed gastric emptying, and increased satiety signaling GIP receptor activation: Additional insulin secretion support and potential effects on lipid metabolism and fat deposition Tirzepatide gained regulatory approval in 2023 and has been extensively studied in Phase 3 clinical trials with larger patient populations and longer durations