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The study included the randomization of 247 adults with NASH without DM, who received pioglitazone (30 mg per day), Vitamin E (800 IU per day) or placebo for 96 weeks

For some patients, an even greater body loss may be required

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Centrally, GLP-1 functions as a neuromodulator, with its receptor widely distributed in the brain, including the hypothalamus, NAc, ventral VTA, area postrema (AP), and potentially PFC [5,16] (refer to Table 1)

These medications target receptors in the brain specifically in the hypothalamus and hindbrain to curb appetite and reduce constant thoughts about food, often referred to as "food noise." "Lots of people describe it as decreasing food noise, which means how much you think about food and how much you crave different foods." Evan Nadler, MD, MBA, Adjunct Associate Professor, George Washington University Myth 5: GLP-1 Medications Are Only for Type 2 Diabetes Although GLP-1 medications were initially created to manage diabetes, they now have FDA approval for chronic weight management in people without diabetes