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The two studies are being presented this week at the joint conference held by the Society for Cardiovascular Angiography & Interventions (SCAI) 2026 Scientific Sessions & Canadian Association of Interventional Cardiology (CAIC)

However, animal models have significant limitations in predicting human autoimmune disease responses

In intact murine islets, blockade of N-type Ca 2+ channels with -conotoxin, but not L-type Ca 2+ channels using nifedipine, abolishes low glucose (1 mM) stimulation of glucagon secretion and blunts the GLP-1-mediated inhibitor effects

To date, tens of thousands of research participants have received GLP-1RAs in RCTs investigating efficacy for improving glycemic control, body weight, and cardiovascular outcomes

Importantly, tirzepatide is not indicated for the treatment of type 1 diabetes or diabetic ketoacidosis

Dose matters
