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Therefore, the activation of the IGF-2/IGF-1R axis may contribute to -cell survival in response to GLP-1, and importantly, the increased IGF-2 secretion may be essential for triggering this response, as also observed in embryonic development (41)

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4 Studies in animals have led to concerns about the risk of acute pancreatitis and medullary thyroid carcinoma (MTC)

These low blood sugar periods even when they are not technically hypoglycemic produce symptoms that feel a lot like fatigue: dizziness, brain fog, shakiness, difficulty concentrating, and a sudden desire to lie down

First, we considered the possibility that responses mediated by GLP-1R might be modulated by the state of the Y1-R