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4,6 A key issue in the physiology of type 2 diabetes (T2DM) is the reduced incretin effect, which mainly results from decreased activity of the primary incretin hormones, GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide)

GLP-1 medications often slow the digestive process, which can lead to occasional bloating, discomfort, and irregular bowel movements

10.1161/HYPERTENSIONAHA.118.10884 [DOI] [PMC free article] [PubMed] [Google Scholar] 13

In contrast, insulin doses were reduced in 5 individuals including 1 participant who discontinued insulin entirely ( Table 2 )
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However, they are also associated with a range of side effects, some of which can be severe
