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GLP-1 receptor agonism: A transformative approach for managing type-2 diabetes and obesity

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After discontinuation, appetite often returns

Notably, treatments with the multi-agonists or GLP1 did not cause signs of nausea/malaise at any time-point tested (272 h), since pica behavior (i.e., kaolin intake) was similar, or even lower, in mice treated with GLP1/E, GLP1/GIP, GLP1/GIP/Glucagon, or GLP1 vs
Jordan says that some patients may only need to take lower amounts, some only need the GLP-1 intermittentlyfor example, every other weekwhile others may even be able to go off it completely

Naunyn Schmiedebergs Arch Pharmacol (2011) 384(2):197207