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When to hold or slow the escalation Several situations warrant pausing at your current dose rather than escalating on schedule: Active weight loss above 1 to 2 pounds per week at your current dose means the medication is working

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In addition to profoundly compromising quality of life and daily functioning, this disorder contributes to the pathogenesis of numerous chronic diseasesincluding hypertension, coronary artery disease, stroke, diabetes, and cognitive impairmentand has been correlated with elevated all-cause mortality risk (46)

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This weekly dosing helps to maintain steady levels of the medication in the body, allowing it to effectively support weight loss by regulating appetite, enhancing satiety, and improving insulin sensitivity

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Response to treatment: the clearest diagnostic clue If a facial rash has been treated with benzoyl peroxide, salicylic acid, adapalene, or doxycycline for more than eight weeks without improvement, perioral dermatitis should be high on the differential

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