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Semaglutide, a GLP-1 receptor agonist approved for type 2 diabetes and weight management, raises important safety questions for patients with ulcerative colitis

In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials

PBS Key take-aways Step-before-GLP-1 PBS now demands that an SGLT2-i be trialled (unless contraindicated) and either: caused intolerance, or failed to achieve 0.5 % (5 mmol/mol) HbA1c reduction after 6 months

Okerson T, Yan P, Stonehouse A, Brodows R

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Furthermore, A-RDN enhanced GLP-1-induced diuresis and natriuresis as well as T-RDN, suggesting that afferent renal nerve is essential for regulating the response of increase in RSNA to GLP-1 described above