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The protective effects of GLP-1 RAs against cardiovascular events have been demonstrated in several studies, thus supporting their application in patients with heart failure with preserved ejection fraction and DM2 ( Taken together, GLP-1 is a major metabolic and regulatory hormone, with many potential therapeutic implications beyond glycemic control, encompassing cardiovascular protection, enhanced renal function, and the potential benefits in hepatic disease

[DOI] [PubMed] [Google Scholar] 122.Jorsal A, Kistorp C, Holmager P, et al

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Weight loss with Semaglutide GLP-1 can present several challenges

2007;293:R983R987

Therefore, the addition of glucose-lowering agents is recommended by the American and European Diabetes Associations to control and/or minimize the risk of cardiovascular disease and microvascular complications [103]