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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Ajumobi AB, Griffin RA

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However, unlike prescription medications with standardized formulations and FDA oversight, probiotic supplements vary significantly in quality, strain viability, and actual content compared to label claims

Nevertheless, uncritical enthusiasm is unwarranted given the pervasive heterogeneity of existing trials, the profound dependence of therapeutic effects on formulation characteristics, and the inherent limitations of predominantly short-duration interventions in a disease defined by decades of progressive metabolic deterioration

The FDAs approval was backed by data from the Phase III KEYNOTE-A18 study, where Keytruda plus CRT reduced the risk of disease progression or death by 41% versus placebo plus CRT, Merck reported