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The prospective, real-world cohort study conducted at Vanderbilt University Medical Center included 105 patients with a baseline BMI greater than 35 kg/m who completed 12 months of GLP-1 RA therapy and achieved a BMI of 30 kg/m through an 18-month Medical Weight Loss Bundle (MWLB) program

For a full list of warnings and side effects, please see the Patient Information Leaflet

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Makki K, Froguel P, Wolowczuk I

Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has shown superior efficacy in glycemic control, weight loss and cardiometabolic outcomes compared to GLP-1 agonists alone

It was concluded that the use of palmitate with a Glu linker was the optimal combination to obtain an appropriate in vivo protraction without compromising receptor potency