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Other actions of GLP-1 that also contribute to restoring glucose regulation in Type 2 diabetes include inhibition of glucagon secretion, slowing of gastric emptying, suppression of appetite and modest reduction in body weight (37, 48, 84, 118)

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Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation

That translates to approximately 4 fewer heart attacks, strokes, or cardiovascular deaths per 100 people over 3 years

In addition, the investigators reported that DA-CH5 was superior to Liraglutide in reducing the activation of microglia and astrocyte (helper cells that maintain the health of neurons), improving energy production in cells (mitochondrial activity), and boosting cellular waste disposal (autophagy)

Yoga, Pilates, and tai chi seem to help but its not clear that theyre any better than other exercise Theres lots of research on back pain and yoga