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The formation of the BCP proceeds through reactive electrophilic intermediates, and these have been suggested to exert biological effects by reaction with protein nucleophiles (14,17)

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All but one showed 50% improvement within 30 days of discontinuation [118]

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Average Sales Price (ASP) is the actual average manufacturer selling price after rebates and chargebacks, as reported to the Centers for Medicare & Medicaid Services (CMS) on a quarterly basis for Part B drugs