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All study participants already had tight glycaemic control, with a mean HbA 1c of 56.1 mmol/mol (7.3%) across the groups at baseline

If side effects persist or grow worse with each dose increase, clinicians usually slow escalation, reduce the dose, or suspend therapy while investigating other causes

Zepbound (November 2023) for chronic weight management Real-world data : Growing post-market evidence supporting efficacy and safety in diverse populations Cardiovascular outcomes : SURPASS-CVOT trial evaluating cardiovascular endpoints Key Differences Summary# Receptor pharmacology : Retatrutide is a triple agonist (GIP/GLP-1/glucagon)

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However, some people continue having mild intermittent nausea or digestive issues even after months at the same dose

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