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However, to impact macro-vascular disease, the drug chosen to lower blood glucose concentration may be more important [6]

[DOI] [PubMed] [Google Scholar] 57.Zhang ZQ, Holscher C

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Additionally, it was found that muscle layer-targeted LGP-MN treatment improves glucose tolerance by increasing the production of gastric-derived glucagon-like peptide-1 (GLP-1), offering unique effects

Vascular and metabolic effects of SGLT2i and GLP-1 in heart failure patients

Beyond its established roles in enhancing insulin secretion, inhibiting glucagon release, and promoting satiety, GLP-1 exerts pleiotropic immune modulatory and anti-inflammatory effects in multiple systems such as the renal, cardiovascular, and central nervous systems [15]