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[27] [28] Adipose tissue produces inflammatory mediators that can exacerbate joint inflammation
Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)
Additionally, patients experienced modest weight loss averaging 2 to 3 kg over 6 months, an unexpected but welcome effect that distinguished GLP-1 receptor agonists from many other diabetes medications that cause weight gain
Post-transplantation diabetes mellitus
Today, there are three GLP-1 weight-loss drugs available: Saxenda
There are a lot of advancements coming in the world of GLP-1s and obesity treatments in general, Wojeck said
