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The GLP-1 receptors may already be partially desensitized from semaglutide use, but the GIP receptors are "fresh" and fully responsive
Expression of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel subunits (sulphonylurea receptor 1 [SUR1] and inward-rectifier potassium channel 6.2 [Kir6.2]) has also been confirmed in K cells, and the addition of tolbutamide, a K ATP channel inhibitor, enhanced GIP release in primary mouse intestinal cultures [31]

However, much more research is needed to fully answer this question
FSAs are employer-sponsored and have shorter contribution windows but higher annual limits in some cases
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Mukai et al., 2011)
