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On April 30, 2026 , the FDA proposed leaving semaglutide, tirzepatide, and liraglutide off the 503B bulks list entirely, saying there is no clinical need for large-scale compounding

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In the SUSTAIN clinical trial program evaluating subcutaneous semaglutide for type 2 diabetes, once-weekly dosing (0.5 mg or 1.0 mg) reduced HbA1c by 1.5% to 1.8% from baseline, with superior glycemic control compared to specific comparators in head-to-head trials (SUSTAIN-7 vs dulaglutide

Furthermore, it must be emphasised that holistic treatment strategies including lifestyle and dietary changes should be included alongside GLP-1 RAs medications