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Preparation 33 Synthesis of Peptide hydrazide (17-mer) (Preparation 33 SEQ ID NO: 32 Hydrazine-CTC resin (1.01 g, loading value: 0.65 mmol/g) is taken in a 40 mL reactor vessel and swollen with 3 x 4 mL DCM (30 s each) followed by 2 x 10 mL DMF (20 min each) on a peptide synthesizer

In 2020, Ozempic was granted an additional indication to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease

Patients taking the drug for four years lost and sustained an average of 10% of their bodyweight while remaining on the medicine, the researchers found, compared to just 1.5% in the placebo group