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10.1016/S2213-8587(21)00203-5 8

It activates the GLP-1 receptor, which in turn slows gastric emptying, inhibits the release of glucagon, and stimulates insulin production

All statistical analyses were conducted using R (R Core Team, 2021), version 4.2.3 with packages: MICE (v 3.15.0) for imputations (van Buuren and Groothuis-Oudshoorn, 2011), MatchThem (v 4.5.2) (Ho et al

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On the contrary, MC4R agonist, setmelanotide, was approved for the rare MC4R-deficiency, BardetBiedl syndrome (BBS), with severe obesity in childhood [10, 23]