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Ozempic mimics the GLP-1 hormone, which signals the brain to feel full and slows the rate food leaves the stomach

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Effect of glucagonlike peptide1 receptor agonists on body weight in adults with obesity without diabetes mellitusa systematic review and metaanalysis of randomized control trials

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58 GLP-2 The primary physiological effect of GLP-2 appears to be within the intestine, where GLP-2 promotes small and large intestinal growth through stimulating cell proliferation and inhibiting apoptosis in the crypt compartment

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Other gut-derived peptides The previously mentioned gut peptides (GLP-1, GIP, and CCK) have been extensively studied for their role in metabolic homeostasis

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In addition, GLP-1mediated activation of PKA upregulates CREB, increasing the expression of IRS2, a cell survival factor, leading to activation of PI3K/PKB and the anti-apoptotic protein Bcl-2 (Wilson et al., 1996

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