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Importantly, the authors demonstrated that the peptides which were most able to produce weight loss without hyperglycaemia demonstrated balanced potency at the GLP-1 and glucagon receptors

These second order effects will become more far reaching as insurance coverage becomes wider for these drugs - this will be the differentiator between the risk/reward being better on the first-order beneficiaries (LLY and NVO) and the second-order plays like short bariatric surgery/sleep apnea/gyms/fast food & CPG

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However, no clinical evidence exists demonstrating better outcomes using potent, short-acting DPP-IV inhibitors instead of longer-acting DPP-IV inhibitors, nor has there been a large study on the efficacy of the cleavage products of GLP-1 (7-36) (and GLP-1 [9-37])

The first drug targeting the GLP-1 receptor was exenatide, released in 2005 as a twice-daily injection to treat type II diabetes

While GLP-1RAs demonstrate promising metabolic and anti-inflammatory effects, their application in treating sepsis remains limited by insufficient clinical evidence, individual variability, and potential side effects