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In contrast, Wegovy and semaglutide-based alternatives affect only GLP-1 pathways

Structure-Activity Relationships and Medicinal Chemistry The optimization of orforglipron from the initial hit compound to a clinical candidate exemplifies modern medicinal chemistry approaches applied to a novel target class

C-EL and PU drafted the manuscript

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Buxton J
Whether thats right after your morning coffee or as part of your bedtime wind-down, anchoring it to an existing habit helps
