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In 2014, naltrexone/bupropion sustained release (Contrave ) and liraglutide 3 mg (Saxenda ) were approved for chronic weight management

12 Place in Therapy The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) developed an algorithm to assist providers in managing type 2 diabetes

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This interesting finding, occurring without weight loss, is consistent with preclinical and clinical studies showing weight-independent effects of GLP-1R agonism on liver steatosis 51,52,53

The authors concluded: The use of GLP-1 agonists should be considered in T1DM patients who are overweight or obese and not at glycemic goals despite aggressive insulin therapy. After conducting clinical trials with a GLP-1 agonist, Novo Nordisk decided not to pursue FDA approval for treating type 1 diabetes

The primary outcome was percentage total weight loss, with safety among secondary outcomes