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A Hamster model of diet-induced obesity for preclinical evaluation of anti-obesity, anti-diabetic and lipid modulating agents

GLP-1 RAs also attenuate activation of the NLRP3 inflammasome, a central driver of neuroinflammation and microglial reactivity in depression [85]

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A large real-world study shows that patients who stop popular GLP-1based weight-loss drugs often return to treatment or try alternative therapies, helping explain why average weight regain after discontinuation may be smaller than expected