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Have you tried fad diets and exercise without seeing the results you want

[MUSIC PLAYING] KWONG: This episode was produced by Rachel Carlson and edited by Brent Baughman

Orange Naturals B12 Drops provide 500mcg of the active form methylcobalamin in a delicious blueberry-flavoured liquid format

Retatrutide (LY3437943): Educational Overview Executive Summary Retatrutide is an investigational triple-agonist incretin therapy activating: GLP-1 receptors GIP receptors glucagon receptors This multi-pathway engagement affects: appetite regulation insulin signaling lipid metabolism hepatic glucose handling energy expenditure References: Coskun T et al., Cell Metabolism , 2022 Jastreboff AM et al., NEJM , 2023 Mechanism of Action GLP-1 Receptor Activation GLP-1 signaling: increases glucose-dependent insulin secretion slows gastric emptying activates satiety pathways in the brain Reference: Drucker DJ, Cell Metabolism , 2018 GIP Receptor Activation GIP signaling: enhances insulin secretion improves adipocyte insulin sensitivity modulates lipid metabolism References: Finan B et al., Nature Medicine , 2013 Nauck MA et al., Diabetes Care , 2021 Glucagon Receptor Activation Retatrutide uniquely activates glucagon receptors

First, the SPF mice utilized in this study were not bred and maintained in gnotobiotic isolators, potentially leading to fundamental differences such as housing, handling, care, and overall mouse husbandry