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This occurs because your stomach and nervous system become less responsive to continuous GLP-1 signaling, similar to how tolerance develops with other long-term medications

Gentle movement often helps energy levels more than complete rest

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PlexusDx providers coordinate with patients' primary care physicians to ensure safe medication management during GLP-1 therapy initiation

Observations from the global registration Phase III trials suggest that tirzepatide (a novel dual GIP/GLP-1 receptor agonist) represent advancement over current GLP-1 analogues, providing enhanced glycaemic and weight benefits with similar gastrointestinal tolerability