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For weight management , NHS eligibility is more restrictive

Stomach paralysis disrupts the normal muscular contractions of the stomach (peristalsis), which help move food into the small intestine

This is a glucose-dependent process, meaning insulin is primarily released when needed, reducing the risk of dangerously low blood sugar

The remaining 65% either have minimal nausea or adapt within 4-6 weeks

CrossRef From Classic to Contemporary, Evolving Therapies in Diabetic Kidney Disease: The Point of View of the Nephrologist and the Diabetologist Micaela Gentile, Marta DAngelo, Maria Rosaria Var, Andrea Mario Bolla, Maurizio Bianco, Roberto Scarpioni Diabetology.2025

Notably, the drug costs about $300 more a month than Zepboundand it also works less well