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9 They should be administrated by injection except for oral semaglutide, limiting their clinical application

We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

Switching from dulaglutide (Trulicity) to semaglutide (Ozempic) According to general recommendations, a 7-day gap is recommended between switching these medications

Indeed, similar to chronic blockade of CNS GLP-1R, viral knockdown of GLP-- expressing neurons in rats increases body mass, and specifically body adiposity [356]