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In absolute terms, that was ~15 kg weight loss on semaglutide vs ~2.5 kg on placebo an unprecedented result for a medication ( [12] )
[DOI] [PubMed] [Google Scholar] 208.Sudhakar M, Silambanan S, Chandran AS, Prabhakaran AA, Ramakrishnan R
And I think its probably both
One of the core reasons is a massive influx in patients utilizing glucagon-like peptide (GLP-1) drugs for the treatment of diabetes and obesity
A considerable number of patients with IBD fail to achieve durable clinical remission
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