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Tirzepatide - SURMOUNT-2, SURMOUNT-3 and SURMOUNT-4 On July 27, 2023, Eli Lilly and Company announced results of SURMOUNT-3 and SURMOUNT-4 in adults with obesity or overweight with weight-related comorbidities, excluding type 2 diabetes

7 However, the incidence of benign PVT increases up to 11% in patients with liver cirrhosis

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Studies in certain small (rodent) and large (canine and feline) animal models of LSDs have shown functional improvement and reduction in lysosomal storage [35]

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Why it matters: Retatrutide can reduce liver fat (a positive effect), but any compound that significantly alters hepatic metabolism warrants liver monitoring