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The compound has been studied in trials lasting up to 68 weeks, which provides useful medium-term data but leaves questions about effects beyond 2 years of continuous use

Additionally, peptides with secondary structures like alpha-helices or beta-sheets may be more susceptible to aggregation

The Haute Autorit de Sant (HAS) recommends that these drugs should be used only as an obesity treatment for patients under the age of 65 who have a body mass index greater than or equal to 35 kg/m2 and only as a second-line treatment, in the event of failure of nutritional management, and in association with a low-calorie diet and physical activity

Mediation analyses show that a majority of the reduction is due to weight loss itself, while smaller improvements may come from weight-independent effects like improved vascular tone and insulin sensitivity

Respiratory events and hypoglycemia mainly occur in patients with pre-existing conditions or concomitant therapies, while individual genetic background may significantly influence pancreatic safety

The most common side effect is nausea, which can be managed through careful dose adjustments