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Therefore, additional preclinical research is necessary to assess the feasibility of targeting vagal innervation at the branch level, such as the hepatic, cardiac, and bronchial branches of the vagus nerve

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In the pivotal SUSTAIN trials examining semaglutide for type 2 diabetes management, vomiting was reported in 5-9% of patients receiving therapeutic doses (0.5 mg or 1 mg weekly subcutaneous injections), compared to approximately 2-3% in placebo groups

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