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Clinical trials show patients who discontinue treatment regain approximately two-thirds of lost weight over the following year, while A1C levels typically rise as the medication's metabolic effects cease

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Conclusion Pharmacovigilance quantitative and qualitative data strengthens evidence for dysesthesias associated with GLP-1R agonists already observed in clinical trials of semaglutide, tirzepatide, and retatrutide

There is also a risk of stomach issues, such as inflammation of the stomach lining and gastroparesis (stomach paralysis)

This means LP(a) particles are much more likely to stick around in the blood, get into blood vessel walls, and cause plaque formation, leading to conditions like atherosclerosis