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The critical DILI case occurred during rapid dose-escalation studies designed to determine optimal dosing parameters for potential late-stage development

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In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects