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Due to DPP-4 and renal clearance, native GLP-1 in humans has a half-life of about 1-2 minutes (89)

GLP-1 receptor agonists are subcutaneous injections delivered into fatty tissue beneath the skin, not into muscle or veins

Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 Randomized Clinical Trial

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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for managing type 2 diabetes, with some now also approved for weight management

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