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However, it should be noted that the reductions were more pronounced in male rats than in female rats (Vallof et al., 2020), suggesting that sex differences in treatment outcome should be further evaluated in upcoming studies

While these medications can aid in initial weight loss, long-term success often depends on sustained behavioural changes, such as diet and exercise modifications

Pedrosa MR, Franco DR, Gieremek HW, et al

doi: 10.2478/rjim-2019-0003 194 ZobelEHRipaRSvon ScholtenBJRotbain CurovicVKjaerAHansenTWet al

Without tailored movement retraining, these shifts can result in: Overworked back muscles, Core instability, Poor coordination or balance reactions

Comparative metabolic and hepatic effects of GLP-1-based mono-, dual-, and triple-agonist therapies GLP-1 receptor signaling Intestinal L-cells serve as the primary source of GLP-1 synthesis, which operates via G-protein coupled receptors present in pancreatic beta cells, gastrointestinal and central neural systems, cardiac tissues, and kidneys [26]