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Attenuation of fasting-induced phosphorylation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus in response to refeeding

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These regions are part of the limbic-hypothalamic circuit (141)

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Similar conformational change was also observed in the tirzepatideGIPRG s , tirzepatideGLP-1RG s , peptide 20GIPRG s and peptide 20GLP-1RG s complexes, compared to peptide-free apo GLP-1R structure 31