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This epigenetic classification proved robust, as similar profiles were observed in both transplanted and diabetic -cells (Dror et al., 2023)

These include: Increased appetite and food cravings , which may work against Wegovy's appetite-suppressing effects Insulin resistance and elevated blood glucose levels , potentially leading to steroid-induced diabetes Fluid retention and weight gain , particularly in the face, neck, and trunk (cushingoid features) Redistribution of body fat to central areas Muscle wasting , which can reduce metabolic rate Patients taking both medications may experience reduced weight loss efficacy compared to those taking Wegovy alone, though the appetite-suppressing effects of Wegovy may help mitigate steroid-induced hunger

Available at: Accessed 7 May 2016

Diabetologia (2018) 61(Suppl 1):S1620 (abstract 714)

It is also used to lower the risk of major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in adults with Type 2 diabetes and heart disease